Biomaterials for Organoids
Timeslot: Friday, April 23, 2021 - 1:45pm to 3:15pm
Track: Engineered Microenvironments
Three-dimensional ex vivo organoid cultures using biomaterial-based assembly and self-assembly have been shown to resemble and recapitulate most of the functionality of diverse multicellular tissues and organs, such as the gut, brain, liver, kidney, and lung. Organoids bridge a gap in existing model systems by providing a more stable system amenable to extended cultivation and manipulation, while being more representative of in vivo physiology. For years, bioengineers have aspired to construct biological systems and manipulate the system in a highly controlled manner with biomaterials. Discovery of new substrates, pathways and growth factors is expected to contribute significantly to clinical protocols and ameliorate concerns related to potential ethical issues. This new "Biomaterials for Organoids" Session will cover the most recent advancements of biomaterial mediated organoid technologies in regenerative medicine, cancer therapy, drug testing, environmental control and monitoring, adaptive sensing, CRISPR-Cas9 genome editing, as well as the large-scale cell manufacturing and reproducible applications of organoids transplantation.
Qun Wang, PhD
Kaitlin Bratlie, PhD
Abstracts will be available for download on April 20, 2021.
246. Gut organoids as a platform for evaluating delivery of nanoparticles to treat inflammatory bowel disease, Zahra Davoudi, Nathan Peroutka-Bigus, Bryan Bellaire, Albert Jergens, Michael Wannemuehler, Qun WangIowa State University, Ames, IA, USA
247. Photoinduced hydrogel network reorganization facilitates in situ modulation of intestinal organoid epithelial shape, Max Yavitt1,2, Michael Blatchley1,2, Peter Dempsey3, Kristi Anseth1,21University of Colorado Boulder, Boulder, CO, USA, 2BioFrontiers Institute, Boulder, CO, USA, 3University of Colorado Anschutz Medical Campus, Aurora, CO, USA
248. Engineered Organotypic Breast Tumor Model Elucidates the Role of Tumor-Stromal Interactions on Dynamic Remodeling of Tumor Microenvironment, Sunil Singh, PhD1, Gary Luker, MD2, Hossein Tavana, PhD11The University of Akron, Akron, OH, USA, 2University of Michigan, Ann Arbor, MI, USA
249. A Hyaluronic Acid-Based Hydrogel Culture Platform for iPSC-derived Midbrain Neuronal Culture, Ze Zhong Wang, PhD1, Jesse Liang, MS1, Zhan Shu, PhD1, Samuel Sances, PhD2, Clive Svendsen, PhD2, Nigel Maidment, PhD1, Stephanie Seidlits, PhD11University of California, Los Angeles, Los Angeles, CA, USA, 2Cedars-Sinai Board of Governors Regenerative Medicine Institute, Los Angeles, CA, USA
250. Micropattern-Guided Cardiac Organoid Production for Developmental Toxicity Screening, Plansky Hoang, PhD1,2, Andrew Kowalczewski1,2, Shiyang Sun1,2, Jeffrey Amack, PhD2,3, Zhen Ma, PhD1,21Syracuse University, Syracuse, NY, USA, 2BioInspired Syracuse Institute for Material and Living Systems, Syracuse, NY, USA, 3State University of New York Upstate Medical University, Syracuse, NY, USA
251. Microstructured hydrogels to guide self-assembly and scalable growth of lung alveolar epithelial organoids, Claudia Loebel, MD PhD1, Leonardo Cardenas, PhD2, Aaron Weiner3, Andrew Vaughan, PhD3, Edward Morrisey2, Jason Burdick, PhD11Penn Center for Pulmonary Biology, University of Pennsylvania, Phildelphia, PA, USA, 2School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA, 3University of Pennsylvania, Philadelphia, PA, USA