Biomaterials for Regulating Immune Responses
Timeslot: Thursday, April 22, 2021 - 11:00am to 12:30pm
This session will focus on development of synthetic or natural biomaterials to regulate immune functions or modulate the metabolism of immune cells. For conditions such as autoimmune diseases, allergies, graft-versus-host disease, and hypersensitivity to biological drugs, biomaterials may offer the potential to induce antigen-specific immune tolerance through novel antigen delivery approaches, or precisely induce local immune suppression by scaffold or targeted drug delivery. Developing biomaterials that modulate the metabolism of immune cells is also an emerging field, because of the ability to selectively regulate immune responses, and provide insight into basic immune regulatory mechanisms.
Shijie Cao, Ph.D.
Jamal Lewis, PhD
Abstracts will be available for download on April 20, 2021.
133. Delivery of STING Agonist Using pBAEs Nanoparticles Inhibits Tumor Growth in Different Tumor Models, Pere Dosta Pons, PhD1,2, Alexander Cryer, PhD1,2, Santhosh Kalash, PhD1,2, Michelle Dion1,2, Shiran Ferber, PhD1,2, Natalie Artzi, PhD1,21Brigham and Women’s Hospital (Harvard Medical School), cambridge, MA, USA, 2Massachusetts Institute of Technology, Cambridge, MA, USA
134. Immunoengineered CCL21 and Beta-Cell Antigen Hydrogel Platform to Induce Tolerance in Type 1 Diabetes, Flavia Zisi Tegou, MS1,2, Diana Velluto, PhD2, Freddy Gonzalez Badillo, MS1,2, Allison Bayer, PhD2,3, Silviya Zustiak, PhD4, Alice Tomei, PhD1,21University of Miami, Miami, FL, USA, 2Diabetes Research Institute University of Miami, Miami, FL, USA, 3University of Miami Miller School of Medicine, Miami, FL, USA, 4Saint Louis University, Saint Louis, MO, USA
135. Succinate based Adjuvant-less Cancer Vaccine Modifies Immunometabolism and Prevent Melanoma Growth in Mice, Sahil Inamdar1, Joslyn Mangal1, Xiaojin Shi1, Marion Curtis2, Haiwei Gu1, Abhinav Acharya11Arizona State University, Tempe, AZ, USA, 2Mayo Clinic, Phoenix, AZ, USA
136. Chemically-Induced Cross-linking of Peptidic Fibrils for Scaffolding Polymeric Particles and Macrophages, Jennifer Armen, BS1, Nathan Schueller2, Nevil Abraham, BS2, Ketki Velankar, MS2, Rachelle Palchesko, PhD3,4, Yong Fan, PhD5,6, Wilson Meng, PhD2,7, Ellen Gawalt, PhD1,71Duquesne University, Chemistry and Biochemistry, Pittsburgh, PA, USA, 2Duquesne University, Pharmaceutical Sciences, Pittsburgh, PA, USA, 3Carnegie Mellon University , Biomedical Engineering, Pittsburgh, PA, USA, 4University of Pittsburgh, Louis J. Fox Center for Vision Restoration, Pittsburgh, PA, USA, 5Allegheny-Singer Research Institute, Allegheny Health Network, Pittsburgh, PA, USA, 6Carnegie Mellon University, Biological Sciences, Pittsburgh, PA, USA, 7McGowan Institute for Regenerative Medicine, Pittsburgh, PA, USA