Engineering Cells and Their Microenvironments SIG - 1

Timeslot: Wednesday, April 21, 2021 - 12:30pm to 2:00pm
Track: Engineered Microenvironments
Room: Virtual


This session will focus on research that describes biomaterials-based approaches for influencing cellular behaviors and fates, which include, for example, proliferation, differentiation, morphological state, motility, matrix production, and life/death. Advances in biomaterial technologies for engineering cells and their microenvironments play instrumental roles in discoveries ranging from elucidation of fundamental biological processes to translation of cellular and material systems to clinics and industry. Work in this area includes biomaterials and biomaterial systems that focus on controlling cells and their environments at the cell scale and talks will encompass engineering microenvironments, biomaterial-influenced cell signaling, technology used in stem cell manufacturing and differentiation, immunoengineering, and biomaterials for cell-based detection and diagnosis. Studies that will be highlighted will range from the development of biomimetic materials providing specific physicochemical cues that elicit desired phenotypic responses to work focused on applications of material systems at the cellular level, for example in cell-based and cell-focused therapies or in understanding the progression of disease, such as COVID-19.

Daniel Harrington, PhD
Chris Highley, PhD
Ram Saraswat, BS
Scott Wood, PhD


Abstracts will be available for download on April 20, 2021.

  • 65. Hydrogel Cultures Reveal Sex Differences in Valvular Myofibroblasts with Links to Genes that Escape X-Chromosome Inactivation, Brian Aguado, PhD, Cierra Walker, Joseph Grim, Megan Schroeder, Dilara Batan, Brandon Vogt, Andrea Gonzales-Rodriguez, Donald Heistad, Leslie Leinwand, Kristi AnsethUniversity of Colorado Boulder, Boulder, CO, USA

  • 66. Laminin interactions with the islet in a 3d reverse thermal gel scaffold protect against cytokine-mediated ?-cell death, Meghana Shivananda Murthy, MS1,2, Nikki Farnsworth, PhD1,21Colorado School of Mines, Golden, CO, USA, 2University of Colorado Anschutz Medical Campus, Aurora, CO, USA

  • 67. Investigating Overload in Triggering Hypertrophic Cardiomyopathy Pathogenesis using iPSC Cardiomyocytes, Jignxuan Guo, MS, Huanzhu Jiang, Kasoorelope Oguntuyo, Brandon Rios, Anand Boodram, Nathaniel Huebsch, PhDWashington University in St. Louis, St. Louis, MO, USA

  • 68. Myofibroblast persistence promotes inflammation via IL-8 secretion in valvular interstitial cells, Cierra Walker, Megan Schroeder, PhD, Leslie Leinwand, PhD, Kristi Anseth, PhDUniversity of Colorado Boulder, Boulder, CO, USA

  • 69. Sliding Hydrogels with Tunable Molecular Mobility Enhance Cartilage formation by Chondrocytes and Stem Cells in a dose-dependent manner, Xinming Tong, Manish Ayushman, Fan YangStanford University, Stanford, CA, USA

  • 70. Supramolecular Click Product Interactions Induce Dynamic Stiffening of Extracellular Matrix-Mimetic Hydrogels, Samantha Holt, Julio Arroyo, Emily Poux, Marissa Heintschel, Austen Fricks, Isabelle Agurcia, Amanda Rakoski, Daniel Alge, PhDTexas A&M University, College Station, TX, USA