Targeted and Stimuli-Responsive Biomaterials for Drug Delivery - 2

Timeslot: Friday, April 23, 2021 - 11:00am to 12:30pm
Track: Functional Biomaterials and Surfaces
Room: Virtual


Targeted and stimuli-responsive biomaterials, are promising for various applications in drug delivery. These "smart" materials can act rapidly at the site of interest while avoiding biological barriers, toxicity, and other potential detrimental effects. Many stimuli have been utilized to trigger stimuli-responsive materials including pH, temperature, ionic strength, chemical and/or mechanical microenvironment, redox potential, and light. Similarly, many targeting mechanisms ranging from passive (e.g., enhanced permeation and retention) to active targeting approaches (e.g., peptide ligands) have been integrated into targeted drug delivery systems. This session will focus on the development and use of such materials for applications including, but not limited to, cancer, infection, orthopedic diseases, cardiovascular disease, and autoimmune diseases.

Anita Shukla, PhD


Abstracts will be available for download on April 20, 2021.

  • 229. Targeted Delivery of a TGF-? Receptor II Inhibitor Using Multifunctional Nanogels to Control Cardiac Fibrosis after Heart Failure, Yu Dang1, Hong Niu, PhD1, Zhaobo Fan, PhD2, Ya Guan1, Ning Gao1, Jianjun Guan, PhD11Washington University in St. Louis, St. Louis, MO, USA, 2The Ohio State University, Columbus, OH, USA

  • 230. Ternary Complex Nanoparticles Enable Sustained Release of Bortezomib for Local Chemotherapy of Hepatocellular Carcinoma, Yicheng Zhang, Hai-quan Mao, Yizong Hu, Ling Li, Florin SelaruJohns Hopkins University, Baltimore, MD, USA

  • 231. CD4 Targeted Nanoparticle Delivery of Eggmanone for T Cell Modulation in Autoimmunity, Christopher Haycook, MS1, Joseph Balsamo2, Evan Glass, MS1, Charles Williams, PhD3, Charles Hong, PhD3, Amy Major, PhD2, Todd Giorgio, PhD11Vanderbilt University, Nashville, TN, USA, 2Vanderbilt University Medical Center, Nashville, TN, USA, 3University of Maryland School of Medicine, Baltimore, MD, USA

  • 232. Oxidation-responsive Magnetic Nanostructure-loaded Bicontinuous Nanospheres for Drug Delivery, Mallika Modak, Sharan Bobbala, Chamille Lescott, Yu-Gang Liu, Vikas Nandwana, Vinayak Dravid, Evan ScottNorthwestern University, Evanston, IL, USA

  • 233. Nanomedicine Targeting to Activated Neutrophil-Platelet Complexes as a Novel Treatment for DVT, Anirban Sen Gupta1, Michelle Cruz1, Jurgis Alvikas2, Nicole Masters3, Kara Bane, Maria de la Fuente1, Marvin Nieman1, Keith Neeves3, Matthew Neal2, Evi Stavrou11Case Western Reserve University, Cleveland, OH, USA, 2University of Pittsburgh Medical Center, Pittsburgh, PA, USA, 3University of Colorado Denver, Anschutz Campus, Aurora, CO, USA

  • Biomimetic Fibrin-Targeted and H2O2-Responsive Nanocarriers for Thrombus Therapy Yi Zhao 1, 2 , Ruosen Xie 1, 2 , Nisakorn Yodsanit1, 2 , Mingzhou Ye 1, 2 , Yuyuan Wang, Shaoqin Gong 1, 2*