Translational organ-on-a-chip technology
Timeslot: Wednesday, April 21, 2021 - 10:45am to 12:15pm
The adoption of microfluidics, lab-on-a-chip, organ-on-a-chip, and other advanced in vitro three-dimensional (3D) modeling techniques are increasingly used in studying normal functions, disease state and developing drugs and theranostics. In addition to advantages they may offer over conventional in vitro cell culture and animal experimentation, these technologies have their own specific properties and limitations. Many approaches use the same biomaterials and microfabrication techniques, and some have advanced to commercialization, but there are still biomaterial and process-based risks which must be reasonably determined, addressed and reduced to an acceptable level. These emerging technologies are noted in priority by FDA, evidenced by participation in the NIH Tissue Chip Consortium and through FDA publications and meetings over the past several years. There are notable examples of products in different countries, and there has been early adoption in various research-level projects. The ultimate promise is the potential to use these technologies as an accepted drug testing modality, which when validated and standardized may largely reduce the use of experimental animals and reduce problems associated with two-dimensional (2D) cell culture models. Adoption will be reflected by industrial advancement of biomedical products well beyond the current limits. This special panel comprises presentations and a discussion focused on various translational considerations of 3D on-a-chip devices, including (1) advancing technology out of the lab, and (2) commercialization of technologies into products for broad clinical use. This will include also discussion of standards, safety, regulatory and funding aspects.
Nureddin Ashammakhi, MD, PhD
Abstracts will be available for download on April 20, 2021.
41. Effects of macrophage phenotype on osteogenic differentiation of MSCs in the presence of wear particles, Qi Gao, PhD1, Claire Rhee1, Masahiro Maruyama1, Zhong Li2, Huaishuang Shen1, Zhenyu Yao1, Bruce Bunnell3, Hang Lin2, Rocky Tuan2, Stuart Goodman11Stanford University, Palo Alto, CA, USA, 2University of Pittsburgh, Pittsburgh, PA, USA, 3University of North Texas, Fort Worth, TX, USA
42. Serial Assessment of Pancreatic Islets in 3D Organoid Microphysiological System Demonstrates Retention of Function
43. Engineered human tissues for assessing cosmic radiation damage, Daniel Tavakol1, Trevor Nash1, Manuel Tamargo1, Youngbin Kim1, Sharon Fleischer, PhD1, Martin Liberman1, Guy Garty, PhD2, Joriene de Nooij, PhD3, David Brenner, PhD2, Gordana Vunjak-Novakovic, PhD11Columbia University Biomedical Engineering, New York City, NY, USA, 2Columbia University Center for Radiological Research, New York City, NY, USA, 3Columbia University Medical Center, New York City, NY, USA
44. CARTiFlo: A Glioblastoma-on-Chip Platform to Assess In Vitro Potency of CAR T Cell Therapy, Chaitanya Tondepu, Meghan Logun, Yang Liu, Leidong Mao, PhD, Lohitash KarumbaiahUniversity of Georgia, Athens, GA, USA
45. The NIH Tissue Chips Program: Novel tools for translational science, Lucie Low NCATS/NIH